c340 Quiz 11

Quiz 11
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1-3. Answer with one of the these liver cell enzymes: (H) hexokinase I; (X) hexokinase IV;
(F) FBPase–1; (G) glucose–6–phosphatase; (K) PFK–1; (R) pyruvate kinase.

an isozyme with a low K_M	inhibited by fructose-2,6-bis-phosphate
an isozyme with a high K_M	activated by fructose-2,6-bis-phosphate
inhibited by ATP	located in the endoplasmic reticulum (ER)
activated by AMP	inhibited when bound by a regulatory protein
not regulated	inhibited when phosphorylated by PKA
activated by fructose-1,6-bis-phosphate

4-5. Write ↑ or ↓ in the blank. "Eventually" means as a result of more than one step.

Activating PKA causes PFK–2 activity to so that, eventually, gluconeogenesis .

Activating PKA causes FBPase–2 activity to so that, eventually, gluconeogenesis .

Activating PKA causes [fructose–2,6–bis-P] to so that, eventually, glycolysis .

Inhibiting PKA causes PFK–2 activity to so that, eventually, gluconeogenesis .

6-10. Use the enzymes involved in glycogen metabolism: (D) debranching enzyme;
(B) branching enzyme; (G) glycogenin; (M) phosphoglucomutase;
(P) glycogen phosphorylase; (S) glycogen synthase; (U) UDP–glucose pyrophosphorylase
Do not use a choice more than once. Answer with only one choice.

glucose–6–P ↔ glucose–1–P	Glucose–1,6–bis-P is an intermediate in the reaction.
Makes an α–(1→4) bond	Hydrolyzes an α–(1→6) bond
Makes an α–(1→6) bond	Adds P_i to break an α–(1→4) bond
Requires UTP as a substrate	Requires UDP–glucose as a substrate
Requires P_i as a substrate	Converts glycogen_n to glucogen_(n+1)
Synthesizes a glycogen primer	Converts glycogen_(n+1) to glycogen_n
Produces UDP–glucose + PP_i	Only required for glycogen synthesis
Produces glucose–1–P	Only required for glycogen degradation

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