Key to Hemoglobin Exercise |
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Hemoglobin Exercise Key
1.
Table 1: Solutes that Bind Hemoglobin |
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O2 |
CO2 |
H+ |
BPG4- |
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Does it bind heme or globin? |
heme |
globin |
globin |
globin |
Does it stabilize R or T? |
R |
T |
T |
T |
number bound per Hb molecule |
4 |
~4 |
~8 |
1 |
The main reason for asking for the number of molecules bound per Hb is to emphasize that they do not bind to the same part of the globin chains. This means that a cumulative effect is possible (adding more modulators causes more of an effect).
Don't memorize this information.
2. a. [H+] increases; b. T is stabilized; c. No 3. On the right: 4. For example, when the oxygen concentration = 4, line A has 90% of Hb sites with O2 bound (R conformation), while line B has only 70% (still mostly R, but less so), and line C has 43%, which means that slightly more than half of the hemoglobin is in the T conformation. |
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